Barrier Patch With Soluble Film and Methods of Improving Skin Appearance

ABSTRACT

A beauty care product is provided. The beauty care product is a multi-layered barrier patch with a water soluble film zone comprising a polyethylene oxide, methylcellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose, and combinations thereof, and a cosmetic composition comprising an effective amount of a skin active agent. The product also has a barrier patch with a backing layer and a pressure sensitive adhesive zone wherein the adhesive zone and the soluble film zone are continuous, discontinuous, or a combination thereof. The soluble film zone or product is capable of changing from a first visual state to a second visual state.

TECHNICAL FIELD

The present invention relates to products comprising a barrier patch and soluble film zones comprising skin active agents for improving skin appearance. The present invention also relates to a method of delivering cosmetic compositions to a target area of the skin via the use of such product.

BACKGROUND OF THE INVENTION

The benefits of using a patch or mask device comprising skin agents to cosmetically treat the skin, have been recognized in the art. A variety of cosmetic patches or devices are commercially marketed or described as being useful for the delivery of skin actives. Patches have also been described in the literature and marketed in the medical field as a useful means for the transdermal administration of drugs.

However, many patches or devices suffer drawbacks which include ineffective release of the active ingredients to the skin. Another drawback is that most products provide no indication to the consumer that the product is effective and that the active is being released from the product to the skin to have its intended effect. Thus many patches result in undesirable in-use characteristics.

Certain beauty care patch systems comprise an active reservoir in which the active is present in solid, liquid or dissolved form and a layer of pressure-sensitive adhesive by which the system can be brought into close contact with the skin. These systems are limited when the active does not diffuse through the adhesive layer, when a chemical reaction occurs between the active and the adhesive, or when the active is insoluble or only poorly soluble in the adhesive.

Different active agents have different chemical, physical and pharmacological properties. Different adhesives also have different chemical and physical properties. The large number of potential combinations of different actives and adhesives make it difficult and in some cases impossible to avoid all potential interactions and solve all therapeutic problems with only one patch system. Thus a multitude of very specific approaches and solutions have been developed for topical patch delivery to the skin, whereby topical activity can be attained and maintained.

Thus an improved multilayered beauty care product is provided. The product comprises a soluble film zone comprising a cosmetic composition comprising a skin active agent and a water soluble film forming polymer, wherein the soluble film zone or product is capable of changing from a first visual state to a second visual state. The product thus provides a signal during use so that the consumer is aware that an effective amount of the active ingredient is provided and released to the skin and thus that the product is effective. This product may also comprise a pressure sensitive adhesive that is substantially separate from the active ingredients so that any interaction between the two is minimized.

SUMMARY OF THE INVENTION

The present invention solves at least one of these problems by incorporating at least one soluble film zone into a beauty care product and the soluble film is directed, in part, to having the correct degree of solubility.

In one aspect a multi-layered beauty care product for applying a skin active agent to the skin, is provided comprising:

a water soluble film zone comprising:

-   -   a water soluble film forming polymer comprising a polymer         selected from the group consisting of polyethylene oxide and         combinations thereof; and     -   a cosmetic composition comprising an effective amount of a skin         active agent;         a barrier patch comprising:     -   a backing layer having a first surface and a second surface; and     -   a pressure sensitive adhesive zone, having an upper surface and         a lower surface, the lower surface of the pressure sensitive         adhesive in contact with the first surface of the backing layer;         wherein the soluble film zone is in contact with either the         first surface of the backing layer, the upper surface of the         adhesive zone, or both, and the soluble film zone or product is         capable of changing from a first visual state to a second visual         state; and preferably the barrier patch is transparent;         preferably the water soluble film zone further comprises an oil         in water or water in oil emulsion and has an initial opacity of         from about 10 to about 100 and preferably the water soluble film         forming polymer is used at a level that is in excess of the         emulsion, by weight of the water soluble film zone whereby         preferably the water soluble film zone may comprise from about         35% to 45% of the emulsion and from about 51% to about 70% of         the water soluble film forming polymer.

In another aspect a multi-layered beauty care product for applying a skin active agent to the skin, is provided comprising:

a water soluble film zone comprising:

-   -   a. a cosmetic composition comprising an effective amount of a         skin active agent;     -   b. a water soluble film forming polymer comprising a polymer         selected from the group consisting of polyethylene oxide and         combinations thereof;     -   c. from about 2% to about 80% by weight of the soluble film zone         of a plasticizer;         a barrier patch comprising:     -   a backing layer having a first surface and a second surface and         a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h; and     -   a pressure sensitive adhesive zone, having an upper surface and         a lower surface, the lower surface of the pressure sensitive         adhesive in contact with the first surface of the backing layer;         wherein the soluble film zone is in contact with either the         first surface of the backing layer, the upper surface of the         adhesive zone, or both; wherein the adhesive zone or backing         layer are substantially free of an effective amount of a skin         active agent; wherein the soluble film zone or product is         capable of changing from a first visual state to a second visual         state with an Opacity Change Index of about 2.5 to about 50         according to the Opacity Test Method.

In another aspect a multi-layered beauty care product for applying a skin active agent to the skin, is provided comprising:

a water soluble film zone comprising:

-   -   a water soluble film forming polymer comprising a polymer         selected from the group consisting of methylcellulose,         hydroxypropyl methylcellulose, hydroxypropylcellulose, and         combinations thereof; and     -   a cosmetic composition comprising;         -   an oil in water or water in oil emulsion; and         -   an effective amount of a skin active agent;     -   optionally from about 2% to about 80% by weight of the soluble         film zone of a plasticizer;         -   wherein preferably the water soluble film zone has an             initial opacity of from about 10 to about 100;             a barrier patch comprising:     -   a backing layer having a first surface and a second surface; and     -   a pressure sensitive adhesive zone, having an upper surface and         a lower surface, the lower surface of the pressure sensitive         adhesive in contact with the first surface of the backing layer;         wherein the soluble film zone is in contact with either the         first surface of the backing layer, the upper surface of the         adhesive zone, or both, and the soluble film zone or product is         capable of changing from a first visual state to a second visual         state optionally having an Opacity Change Index of about 2.5 to         about 50 according to the Opacity Test Method; wherein         preferably the adhesive zone or backing layer is substantially         free of an effective amount of a skin active agent;

In an aspect the adhesive zone is continuous and the soluble film zone may be continuous or discontinuous. The beauty care product may be applied to any keratinous tissue.

BRIEF DESCRIPTION OF THE DRAWINGS

While the specification concludes with claims that particularly point out and distinctly claim the invention, it is believed that the present invention will be better understood from the following description of aspects, taken in conjunction with the accompanying drawings in which:

FIG. 1 is a top plan view of a beauty care product comprising discontinuous soluble film zones and a continuous adhesive zone, as shown and described herein.

FIG. 2A is a cross section taken along 2A-2A of FIG. 1.

FIG. 2B is an alternative cross section of a beauty care product as shown and described herein.

FIG. 3 is a top plan view of a beauty care product comprising discontinuous soluble film zones and discontinuous adhesive zones, as shown and described herein.

FIG. 4 is a cross section taken along 4-4 of FIG. 3.

FIG. 5 shows a product showing an alternative pattern of discontinuous soluble film zones.

FIG. 6 shows a product showing an alternative pattern of the discontinuous soluble film zones.

FIG. 7 are photographs showing a multilayer beauty care product, applied to the skin, comprising a soluble film zone wherein in the left photograph the soluble film zone is in a first visual state and the soluble film zone changes from the first visual state to a second visual state in the right photograph.

FIG. 8 is a photograph showing a soluble film cast on a Mylar backing.

FIG. 9 is a photograph showing a soluble film cast on a Mylar backing wherein the soluble film comprises a second visual state.

FIG. 10 shows a table with the Opacity Change Index for several samples of soluble film.

FIG. 11 show a graph representing Franz cell penetration of various aspects.

FIG. 12 is an image showing an oil in water emulsion with a water soluble polymer.

FIG. 13 is an image showing the emulsion of FIG. 12 dried into a film.

FIG. 14 is an image of the film of FIG. 13 after it is exposed to humidity.

FIG. 15 is an image showing an oil in water emulsion with a water soluble polymer.

FIG. 16 is an image showing the emulsion of FIG. 15 dried into a film.

FIG. 17 is an image showing the emulsion of FIG. 15 dried into a film.

FIG. 18 is an image showing the film of FIGS. 16 and 17 after exposed to humidity.

FIG. 19 is an image showing the film of FIGS. 16 and 17 after it is re-dried overnight.

DETAILED DESCRIPTION OF THE INVENTION

While the specification concludes with the claims particularly pointing out and distinctly claiming the invention, it is believed that the present invention will be better understood from the following description.

All percentages and ratios used herein are by weight of the total composition. All numeric ranges are inclusive of narrower ranges; delineated upper and lower range limits are interchangeable to create further ranges not explicitly delineated. All ratios are weight ratios, unless specifically stated otherwise. All ranges are inclusive and combinable. The number of significant digits conveys neither a limitation on the indicated amounts nor on the accuracy of the measurements. All numerical amounts are understood to be modified by the word “about” unless otherwise specifically indicated. Unless otherwise indicated, all measurements are understood to be made at approximately 25° C. and at ambient conditions, where “ambient conditions” means conditions under about 1 atmosphere of pressure and at about 50% relative humidity.

As used herein, “molecular weight” or “Molecular weight” refers to the weight average molecular weight unless otherwise stated. Molecular weight is measured using industry standard method, gel permeation chromatography (“GPC”).

The compositions of the present invention can comprise, consist essentially of, or consist of, the essential components as well as optional ingredients described herein. As used herein, “consisting essentially of” means that the composition or component may include additional ingredients, but only if the additional ingredients do not materially alter the basic and novel characteristics of the claimed compositions or methods.

The term “apply” or “application” as used in reference to a composition, means to apply or spread the compositions onto a substrate such as the human skin surface or epidermis.

The term “dermatologically acceptable,” as used herein, means that the compositions or components thereof so described are suitable for use in contact with mammalian keratinous tissue without undue toxicity, incompatibility, instability, allergic response, and the like.

The term “facial skin surface” as used herein refers to one or more of forehead, periorbital, cheek, perioral, chin, and nose skin surfaces. While facial skin surfaces are of concern and are exemplified herein, other skin surfaces may be treated with the compositions and methods of the present invention, for example, surfaces typically not covered by clothing such as facial skin surfaces, hand and arm skin surfaces, foot and leg skin surfaces, and neck and chest skin surfaces (e.g., decolletage).

As used herein “healthy skin” means that the physical barrier function of the epidermis and the dermis is maintained intact for example, the stratum corneum of skin is intact, and is not physically disrupted, removed, subject to reduction, wounded, altered or ablated using mechanical, optical, or thermal means.

The term “keratinous tissue,” as used herein, refers to keratin-containing layers disposed as the outermost protective covering of mammals (e.g., humans, dogs, cats, etc.) which includes, but is not limited to, skin, mucosa, lips, hair, toenails, fingernails, cuticles, hooves, etc.

The terms “topical application”, “topically”, and “topical”, as used herein, mean to apply (e.g., spread, spray) the compositions of the present invention onto the surface of the keratinous tissue.

As used herein, “effective amount” means an amount of a compound or composition sufficient to significantly induce a positive keratinous tissue benefit, including independently or in combination with other benefits disclosed herein. This means that the content and/or concentration of agent in the formulation is sufficient that when the formulation is applied with normal frequency and in a normal amount, the formulation can result in the treatment of one or more undesired keratinous tissue conditions (e.g., skin wrinkles). For instance, the amount can be an amount sufficient to inhibit or enhance some biochemical function occurring within the keratinous tissue. This amount of the skin care agent may vary depending upon the type of product, the type of keratinous tissue condition to be addressed, and the like.

The term “safe and effective amount” as used herein means an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive keratinous tissue appearance, including independently or in combinations with the benefits disclosed herein, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.

As used herein, the term “water impermeable” includes materials or objects through which water in its liquid state does not pass.

The term “substantially free of” refers to an amount of a material that is less than 2%, 1%, 0.5%, 0.25%, 0.1%, 0.05%, 0.01%, or 0.001% by weight, of product, the barrier patch, the water soluble film zone, the water soluble film forming polymer, or the backing layer of the barrier patch. “Free of” refers to no detectable amount of the stated ingredient or thing.

“Bio-based content” refers to the amount of carbon from a renewable resource in a material as a percent of the mass of the total organic carbon in the material, as determined by ASTM D6866-10, Method B. Note that any carbon from inorganic sources such as calcium carbonate is not included in determining the bio-based content of the material.

“Biodegradation” refers to a process of chemical dissolution of materials by microorganisms or other biological means.

“Bio-identical polymer” refers to polymers that are made from monomers where at least one monomer is derived from renewable resources. For instance, a bio-identical polyolefin is made from olefins that are derived from renewable resources, whereas a petro-based polyolefin is made from olefins typically derived from non renewable oil or gas.

“Bio-new polymer” refers to polymers that are directly derived (i.e., no intermediate compound in the derivation process) from renewable resources. Such renewable resources include cellulose (e.g. pulp fibers), starch, chitin, polypeptides, poly (lactic acid), polyhydroxyalkanoates, and the like.

“Monomeric compound” refers to an intermediate compound that may be polymerized to yield a polymer.

As used herein, the term “nonwoven” means a porous, fibrous material made from continuous (long) filaments (fibers) and/or discontinuous (short) filaments (fibers) by processes such as, for example, spunbonding, meltblowing, carding, and the like. Nonwoven webs do not have a woven or knitted filament pattern.

“Petrochemical” refers to an organic compound derived from petroleum, natural gas, or coal.

“Petroleum” refers to crude oil and its components of paraffinic, cycloparaffinic, and aromatic hydrocarbons. Crude oil may be obtained from tar sands, bitumen fields, and oil shale.

“Polymers derived directly from renewable resources” refer to polymers obtained from a renewable resource without intermediates. Typically, these types of polymers would tend be “bio-new”.

“Post-consumer recycled polymers” refer to synthetic polymers recovered after consumer usage and includes recycled polymers from plastic bottles (e.g., laundry, milk, and soda bottles).

“Renewable resource” refers to a natural resource that can be replenished within a 100 year time frame. The resource may be replenished naturally, or via agricultural techniques. Renewable resources include plants, animals, fish, bugs, insects, bacteria, fungi, and forestry products. They may be naturally occurring, hybrids, or genetically engineered organisms. Natural resources such as crude oil, coal, and peat which take longer than 100 years to form are not considered to be renewable resources.

Water Soluble Film Zone

The water soluble film zone comprises a water soluble film forming polymer and a cosmetic composition comprising an effective amount of a skin active agent. The water soluble film forming polymer forms a water soluble film preferably selected from the group of water soluble films that also comprise a solubility defined by an Opacity Change Index of about 2.5 to about 50 according to the Opacity Test Method herein. As used herein “water-soluble film” means a film that dissolves according to the dissolution method herein. By virtue of this feature, the product provides a signal to the user through a change in opacity of the soluble film zone, such as when the soluble film is occluded on the skin by a backing layer having a low breathability with a low WVTR as provided herein.

In an aspect the water soluble film zone comprises from about 30% to about 99% or from about 40% to about 90%, more preferably from about 50% to about 75% of a water soluble film forming polymer such as polyethylene oxide, methylcellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose, and combinations thereof.

As used herein a “low water environment” of the skin, means the humidity or moisture provided, under occlusion, from the inner skin layer(s) of healthy skin to the surface of the skin via the pores in the skin. This may comprise components of sweat, sebum or oil. For example a low water environment includes the humidity build up on the skin when the product herein is applied to the skin for about 1 to 8 hours or longer, the product comprising a backing layer having a low breathability (e.g. low WVTR, the proper thickness, etc.), as provided herein.

In addition to being water soluble, the soluble films herein, in an aspect, are capable of changing from a first visual state to a second visual state wherein the first visual state comprises a first opacity and the second visual state comprises a second opacity that is lower than the first opacity; and the change in opacity is capable of being observed by a consumer. Moreover, in an aspect the change from a first visual state to a second visual state is represented by an Opacity Change Index of the water soluble film herein and is from about 2.5 to about 50, or from about 3 to about 40 or from about 5 to about 20 or from about 2.5 to about 45 or about 3 to about 45.

In an aspect the soluble film zone comprises a skin active agent wherein the skin active agent is only minimally released, if at all, from the soluble film zone in the dry form prior to use and/or prior to exposure to the low water environment and/or in the absence of humidity or water. When humidity, contacts the soluble film zone, softening, dissolution or breakdown, begins to occur, thereby enabling the skin active to migrate out of the soluble film zone and/or penetrate to the skin surface or into the skin. In an aspect in the presence of humidity, skin active agents present in the soluble film zones are believed to be more readily available to the skin due to the faster rates of diffusion through the soluble film zone.

The soluble film zone or product is thus capable of changing from a first visual state to a second visual state wherein the first visual state comprises a first opacity and the second visual state comprises a second opacity that is lower that first opacity. As this transformation occurs, the skin active agent may be released from the product to the skin of the user and be absorbed into the skin to have the intended effect.

FIG. 10 shows a table with the Opacity Change Index for several samples of water soluble film comprising polyethylene oxides.

Without being bound by theory, the water soluble film or film zone dissolves, disintegrates, and/or loses its physical integrity when exposed to low water environments. For example the water soluble film prior to exposure to a low water environment, is a dry film comprising a water soluble film forming polymer and where the polymer exists in a solid, semi-crystalline form with high enough % crystallinity with crystallites present that refract light in a particular way. Once the water soluble film is exposed to a low water environment and/or the environment provided in the Opacity Method herein and/or is occluded on the skin as described herein, crystallinity changes to create a different refraction of light, for example less crystallites to refract light, such that a visible change in opacity occurs.

In an aspect, the oil in water or water in oil emulsion has an initial opacity of from about 10 to about 100, preferably from about 10 to about 70, or from about 12 to about 65, or from about 14 to about 50.

The opacity or initial opacity may be provided in the water soluble film zone from the crystalline structure of the water soluble polymer. It may also be provided from the structure of the emulsion such as from the droplets of the emulsion, e.g. the dispersed oil phase droplets in an oil in water emulsion, wherein the droplets interfere with the pathway of light. Without being limited by theory these droplets are trapped inside the film zone. In an aspect, the particles or droplets are crystalline and may be derived from, for example, the wax phase of the skin cream emulsion. Various cosmetic compositions comprising emulsions are disclosed in U.S. Pat. No. 5,972,359, Sine et al., issued on Oct. 26, 1999.

In an aspect, prior to use by the consumer, the water soluble film zone is substantially free of water or may comprise less than 15%, less than 12%, or less than 10%, water, or comprise about 0.001% to about 15% water, or about 0.05% to about 10%, water, or about 0.05% to about 3%, water, by weight of the soluble film zone.

Preferred water-soluble materials for the soluble film zone are polymeric materials, preferably polymers which may be formed into a film or sheet. The water-soluble film zone can, for example, be obtained by casting, blow-molding, extrusion or blown extrusion of the polymeric material, as known in the art.

Preferred polymers, copolymers or derivatives thereof suitable for use as water-soluble film for the soluble film zone are selected from polyethylene oxides, methylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, and combinations thereof.

Preferred water-soluble films are made from polyethylene oxides such as polyethylene oxide films or polyethylene glycol, include Polyox, sold by the Dow Chemical Company. Polyethylene oxides include Polyox WSR N-10 (having a molecular weight of 100,000), WSR N-80 (with a molecular weight of about 200.000). WSR N750 (with a molecular weight of about 300,000), WSR-205 (with a molecular weight of about 600,000), WSR-1105 (with a molecular weight of about 900,000), of corresponding solubility characteristics. In an aspect the water soluble film comprises a polyethylene oxide having a molecular weight from about 500 to about 10,000,000 or from about 10,000 to about 1,000,000 or from about 100,000 to about 300,000 or from about 150,000 to about 250,000.

Other preferred water soluble film forming polymers comprise plasticized methylcellulose and/or plasticized hydroxypropyl methylcellulose and/or plasticized hydroxypropylcellulose. As used herein, “plasticized” means a composition of methylcellulose or hydroxypropyl methyl cellulose or hydroxypropylcellulose, and plasticizer wherein the plasticizer is used at a level of from about 2% to about 80% or about 2% to about 60%, or from about 10% to about 50% or from about 20% to about 45% by weight of this composition. The hydroxypropyl methylcellulose may be Methocel E5LV, a water soluble cellulose ether of low viscosity available from Dow/Coloron LTD. Other Methocel grades that may be used include Methocel E3LV, Methocel E6LV, Methocel E15LV, Methocel E50LV, and Methocel K3LV.

The polyethylene oxide polymers or methylcellulose or hydroxypropyl methylcellulose or hydroxypropylcellulose polymers may be combined with additional polymers, for example, polymers, copolymers or derivatives thereof which may be other water-soluble film forming polymers. The additional polymers may be selected from polyvinyl alcohols, polyvinyl pyrrolidone, polyalkylene oxides, acrylamide, acrylic acid, cellulose, cellulose ethers, cellulose esters, cellulose amides, polyvinyl acetates, polycarboxylic acids and salts, polyaminoacids or peptides, polyamides, polyacrylamide, copolymers of maleic/acrylic acids, polysaccharides including starch and gelatin, natural gums such as xanthum and carragum, polyacrylates and water-soluble acrylate copolymers, polymethacrylates, methylcellulose, carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, dextrin, maltodextrin, salts thereof, and combinations thereof. In an aspect the water soluble film zone comprises polyethylene oxide polymer and an additional polymer selected from the group consisting of polyvinyl alcohols, polyvinyl alcohol copolymers, starch, methylcellulose, carboxymethylcellulose sodium, hydroxyethyl cellulose, hydroxypropyl methylcellulose and combinations.

Also suitable are mixtures of polyethylene oxide polymers having different molecular weights. The additional polymers may have molecular weights, preferably from about 1,000 to 1,000,000, more preferably from about 50,000 to 300,000 yet more preferably from about 20,000 to 150,000.

Preferably, the level of water soluble film forming polymer in the water-soluble film zone in the dry state, is from about 20% to about 90%, or from about 45% to about 85% or is from about 50% to about 70%.

Additional water-soluble materials for the soluble film zone may be selected from polyethylene glycol, pullulan, carbohydrate polymers such as natural polysaccharide or derivates including pectin and derivatives, sodium alginate, methyl methacrylate copolymer, carboxyvinyl polymer, amylase, pectin, chitin, chitosan, levan, elsinan, collagen, gelatine, zein, gluten, soy protein isolate, whey protein isolate, casein, gums (such as guar, gum Arabic, tragacanth gum, xanthan gum, gellan sodium salt, gum ghatti, okra gum, karaya gum, locust bean gum, tara gum, quince seed gum, fenugreek seed gum, scleroglucan, psyllium seed gum, tamarind gum, oat gum, quince seed gum, rhizobium gum, biosynthetic gums, Khaya grandifolia gum, pectin, arabian, Konjac mannan, alactomannan, funoran, acetan, welan, rhamsan, furcelleran, succinoglycan, scleroglycan, and dextran, flaxseed gum), propyleneglycol, alginate, starches (such as amylose, amylopectin, modified starches, hydroxyethyl starch, carboxymethyl starch, high amylose starch, hydrooxypropylated high amylose starch, biosynthetic processed starch, starches such as rice, corn, potato, and wheat), dextrans, dextrins and maltodextrins, konjac, acemannan from aloe, carrageenans, scleraglucan, succinoglucan, larch arabinogalactan, chondroitin sulfates, hyaluronic acid, curdlan, deacetylatedkonjac, water soluble non-gelling polypeptide or protein (such as gelatins, albumins, milk proteins, soy protein, and whey proteins), hydrocolloids (such as synthetic hydrocolloids exemplified by polyethylene-imine, hydroxyethyl cellulose, sodium carboxymethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, polyacrylic acids, low molecular weight polyacrylamides and their sodium salts (carbomers), polyvinylpyrollidone, polyethylene glycols, polyethylene oxides, polyvinyl alcohols, pluronics, tetronics, and other block co-polymers, carboxyvinyl polymers, and colloidal silicon dioxide, soluble polyesters, natural seaweeds, natural seed, natural plant exudates, natural fruit extracts, glycyrrhizic acid, polyacrylic acid, vinyl polymers, cationic polymers, acrylic polymers (such as sodium polyacrylate, polyethyleacrylate and polyacrylamide), and combinations.

In an aspect the water soluble film zone comprises a polyethylene oxide and an additional polymer selected from the group consisting of polyethylene oxide polymer, polyvinyl alcohols, polyvinyl alcohol copolymers, starch, methylcellulose, carboxymethylcellulose sodium, hydroxyethyl cellulose, hydroxypropyl methylcellulose and combinations.

In another aspect, the cosmetic composition may comprise a water in oil or an oil in water emulsion to be combined with a water soluble film forming polymer. As an example, an oil in water emulsion composition such as Olay skin care product may be combined with polyethylene oxide such as Polyox WSR N-80 or methylcellulose or hydroxypropyl methylcellulose such as Methocel E5LV and used as the water soluble film zone. The water soluble film forming polymer may be used in excess of the composition comprising the oil in water emulsion and skin active agent. In an aspect, thus, the water soluble film zone may comprise:

-   -   a.) from about 40% to about 70%, preferably from about 53% to         about 70%, by weight of the soluble film zone, of a water         soluble film forming polymer;     -   b.) from about 30% to about 60% by weight of the soluble film         zone, of a cosmetic composition comprising a water in oil or an         oil in water emulsion and an effective amount of a skin active         agent and optionally a safe and effective amount of a         plasticizer.         In an aspect, the ratio of b) to a) in the soluble film zone, is         from about 30:70 to about 70:30 or from about 40:60 to about         60:40 or about 45:55 to about 55:45 in either the wet or dry         state. In another aspect the ratio of b) to a) is less than         50:50.

In order to further increase the initial opacity, in one aspect, the emulsion used in the present invention may be colored by the use of suitable dyes and pigments. The emulsion may comprise a colorant which may be selected from the group consisting of organic pigments, inorganic pigments, interference pigments, lakes, natural colorants, pearlescent agents, dyes, and mixtures thereof. In an embodiment the pigments, lakes and/or dyes are hydrophobic. Other dyes and pigments are disclosed in International Cosmetic Ingredient Dictionary and Handbook, 10^(th) Edition, Volume 3, 2004, Colorants. pp. 2194-2197. Opacity of the emulsion may be obtained by dispersing colorants, such as titanium dioxide or white pigments, into the emulsion. Colored pigments provide opacity by absorbing and/or scattering visible light (400 nm-700 nm). Pigments may be dry colorants that are usually ground into a fine powder before incorporation in another material. Pigments may come in different forms, such as white oxide powders which scatter light, or dark colored powders that absorb and scatter light. Titanium dioxide (TiO₂) is a multifaceted material when used in applications and has long been established as a leading white pigment. In an aspect emulsion may comprise a safe and effective amount of a colorant, and/or from about 0.001% to about 5% by weight of the emulsion, of a colorant; in another aspect from about 0.05% to about 3% by weight of the emulsion, of a colorant.

In another aspect to increase the initial opacity the emulsion may comprise fatty alcohols that are for example white waxy solids, such as cetearyl alcohol, cetyl alcohol, myristyl alcohol and behenyl alcohol which are such white, waxy solids. Cetyl alcohol and stearyl alcohol are the two major components of cetearyl alcohol. Other fatty alcohols that may contribute to the opacity function may include those that have a free primary, secondary, or tertiary hydroxyl group attached to a long chain group. Fatty alcohols are usually long chain primary alcohols, but they can also range from as few as 4-6 carbons to as many as 22-26 carbons. They can also be unsaturated and have methyl branching. In an aspect the emulsion may comprise a safe and effective amount of a fatty alcohol, and/or from about 0.001% to about 30% by weight of the emulsion, or from about 0.001% to about 10%, or in another aspect from about 0.05% to about 5% by weight of the emulsion, of a fatty alcohol.

FIG. 12 is an image (20× Bright Field Microscopy) showing an oil in water emulsion with Methocel as the water soluble polymer. Thus FIG. 12 is a combination of Methocel E5LV and an oil in water emulsion, similar to the oil in water emulsion in the Example, at a ratio similar to the ratio in the Example. In FIG. 12 the structure of the emulsion is shown prior to drying the emulsion into a film. This structure may be maintained upon drying the emulsion into a film as shown in FIG. 13. The emulsion of FIG. 12 is dried into a film which is shown in FIG. 13 (20× Cross Pol Microscopy). Thus FIG. 13 is a film comprising Methocel and a skin cream comprising an oil in water emulsion. As can be seen in FIG. 13, the skin cream particles are dispersed in an amorphous Methocel matrix. FIG. 14 (20× Bright Field Microscopy) shows the film of FIG. 13 after it is exposed to humidity. The Methocel matrix appears solvated with water. The skin cream droplets/spherulites are dispersed throughout.

FIG. 15 is an image (20× Bright Field Microscopy) showing PEO in ethanol/water combined with a skin cream comprising an oil in water emulsion similar to the Example. Many of the particles are spherical droplets dispersed in liquid. The droplet diameter is estimated to be approximately 5 μm to 20 μm. FIGS. 16 (5× Cross Pol Microscopy) and 17 (5× Bright Field Microscopy) show an image of the emulsion of FIG. 15 dried into a film. Similar sized droplets can be observed in the film. The PEO film matrix has large spherulitic crystallites which extend across the entire film.

FIG. 18 is an image (5× Cross Pol Microscopy) that shows the film of FIGS. 16 and 17, after 2 hours of saturated humidity treatment. High humidity treatment appears to dissolve the PEO crystallites and makes the sample appear more transparent. PEO matrix becomes isotropic/amorphous due to solvation by water. The skin cream droplets/spherulites are dispersed throughout. FIG. 19 is an image (5× Cross Pol Microscopy) that shows the film of FIG. 18 after it has been re-dried overnight.

Plasticizer

The water soluble film zone herein can also comprise one or more plasticizers. For example, it can be beneficial to add plasticizers at a level of from about 2% to about 80% or about 2% to about 60%, by weight of the soluble film zone or the water soluble film forming polymer, or from about 10% to about 50% or from about 20% to about 45% by weight. The plasticizers may be, for example, glycerol, ethylene glycol, diethylene glycol, hexylene glycol, triethylene glycol, propylene glycol, polyethylene glycol, polypropyl glycol, alkyl citrate, sorbitol, pentaerythritol, glucamine, N-methylglucamine, sodiumcumenesulfonate and mixtures thereof. In one aspect the plasticizer is glycerol. Other plasticizers may include vegetable oil, polysorbitols, polyethylene oxide, dimethicone, mineral oil, paraffin, C1-C3 alcohols, dimethyl sulfoxide, N, N-dimethylacetamide, sucrose, corn syrup, fructose, dioctyl-sodium-sulfo-succinate, triethyl citrate, tributyl citrate, 1,2-propylenglycol, mono, di- or triacetates of glycerol, natural gums, citrates, and mixtures thereof.

Optional Ingredients for Soluble Film Zone

The water soluble film zone or water soluble film forming polymer herein can also comprise one or more optional ingredients. Optional ingredients include bulking agents, fillers, diluents, surfactants, stabilizing agents, emulsifiers, thickeners, preservatives, binders, colorants, pigments, solubilizing agents, wetting agents, water soluble inert fillers, buffering agents, permeation enhancers, and combinations. Thickeners may include gum arabic, carrageenan, karaya gum, gum tragacanth, carob gum, quince seed or Cydonia oblonga, casein, dextrin, gelatin, sodium pectate, sodium alginate, methyl cellulose, CMC, hydroxy ethyl cellulose, hydroxypropyl cellulose, polyvinyl alcohol, PVM, PVP, sodium polyacrylate, carboxy vinyl polymer, locust bean gum, guar gum, tamarind gum, cellulose dialkyl dimethylammonium sulfate, xanthan gum, aluminum magnesium silicate, bentonite, hectorite, AIMg silicate or beagum, laponite, and silicic acid anhydride.

Surfactants may include mono and diglycerides of fatty acids and polyoxyethylene sorbitol esters, such as, Atmos 300 and Polysorbate 80, pluronic acid, and sodium lauryl sulfate.

Stabilizing agents may include xanthan gum, locust bean gum and carrageenan, guar gum, sugars, polyols, amino acids or methylamines. Emulsifying agents may include triethanolamine stearate, quaternary ammonium compounds, acacia, gelatin, lecithin, bentonite, veegum, sodium benzoate.

Permeation enhancers may include azone, alcohol, dimethyl-sulfoxide, monovalent, saturated and unsaturated aliphatic and cycloaliphatic alcohols having 6 to 12 carbon atoms such as cyclohexanol, lauryl alcohol, and the like; aliphatic and cycloaliphatic hydrocarbons such as mineral oil; cycloaliphatic and aromatic aldehydes and ketones such as cyclohexanone; N,N-di(lower alkyl)acetamides such as N,N-diethyl acetamide and N,N dimethyl acetamide, N,N-dimethyl acetamide, N-(2-hydroxyethyl)acetamide and the like; aliphatic and cycloaliphatic esters such as isopropyl myristate and lauricidin; N,N-di(lower alkyl) sulfoxides such as decylmethyl sulfoxide; essential oils, nitrated aliphatics, aliphatic and cycloaliphatic hydrocarbons such as N-methyl-2-pyrrolidone and azone; salicylates, polyalkylene glycol silicates; aliphatic acids such as oleic acid and lauric acid, terpines such as cineole, siloxanes such as hexamethyl siloxane; and mixtures.

DISCUSSION OF THE FIGURES

Exemplary aspects of the product 1 are shown in FIGS. 1, 2A, 2B, 3 and 4. FIGS. 1, 2 A and 2B show product 1 comprising a barrier patch 2 having a pressure sensitive adhesive 3 and a backing layer 4. FIG. 2A is the cross section of FIG. 1 taken along 2A-2A. FIG. 1 shows a plurality of soluble film zones 6 to create a series of parallel stripes offset to the longitudinal axis of the product 1. The product 1 thus has alternative rows of stripes of the soluble film zones 6 applied to the upper surface 16 of the pressure sensitive adhesive 3.

The product 1 further comprises a soluble film zone 6 having an effective amount of a skin active agent 8. The backing layer 4 further comprises a first surface 10 and a second surface 12. The pressure sensitive adhesive 3 is in contact with at least part of the first surface 10 of the backing layer 4 to form a pressure sensitive adhesive coated region 14 of the first surface 10. The product 1 may further comprise a cosmetic composition comprising an effective amount of a skin active agent 8. In one aspect the pressure sensitive adhesive 3 also comprises the cosmetic composition. In other aspects the cosmetic composition and skin active agent 8 is distributed to some extent and/or is homogeneously distributed throughout the soluble film zone 6. The product 1 has a skin facing surface 5. The skin facing surface 5 of the product 1 may comprise the upper surface 16 of the pressure sensitive adhesive, the top surface 22 of the water soluble film zone and/or the first surface 10 of the backing layer.

In an aspect of FIGS. 1, 2A, 2B, and 3, the products 1 and 40 are crescent shaped. However this shape is not intended to limit the invention.

FIG. 2B is an alternative cross section of the product of FIG. 1 also taken along 2A-2A. FIG. 2 B shows the product 1 comprising a barrier patch 2 having a pressure sensitive adhesive 3 and a backing layer 4. The product 1 further comprises a soluble film zone 6 having an effective amount of a skin active agent 8. The backing layer 4 further comprises a first surface 10 and a second surface 12. The pressure sensitive adhesive 3 is in contact with at least part of the first surface 10 of the backing layer 4 to form a pressure sensitive adhesive coated region 14 of the first surface 10. The backing layer 4 comprises 3 layers: a non-foamed first layer 26, a foamed second layer 28 and a non-foamed third layer 30. The pressure sensitive adhesive comprises an upper surface 16 and a lower surface 18. The soluble film zone 6 also comprises a top surface 22 and a bottom surface 24. As shown in FIG. 2B the bottom surface 24 of the plurality of soluble film zones 6 are in contact with the upper surface 16 of the pressure sensitive adhesive 3. As shown in FIGS. 1, 2A and 2B the soluble film zones 6 and the pressure sensitive adhesive 3 are substantially separate and the pressure sensitive adhesive zone 6 is continuous.

FIGS. 3 and 4 show a product 40 comprising a barrier patch 42 having a pressure sensitive adhesive 43 and a backing layer 44. FIG. 4 is the cross section of FIG. 3 taken along 4-4. The product further comprises a plurality of discontinuous soluble film zones 46 having an effective amount of a skin active agent 48. The backing layer 44 further comprises a first surface 50 and a second surface 52. The pressure sensitive adhesive 43 is in contact with at least part of the first surface 50 of the backing layer 44 to form a plurality of pressure sensitive adhesive coated regions 54 of the first surface 50 of the backing layer 44. The product 40 may further comprise a cosmetic composition comprising an effective amount of a skin active agent 48. In one aspect the skin active agent 48 is distributed to some extent and/or homogeneously distributed throughout each of the plurality of the soluble film zones 46. As shown in FIGS. 3 and 4, the plurality of soluble film zones 46 and the adhesive zone 43 are substantially separate. In FIG. 4 the soluble film zones 46 are in contact with the first surface 50 of the backing layer 44. As shown in FIG. 4, in an aspect the top surface 62 of the soluble film zones and the upper surface 66 of the pressure sensitive adhesive zone 43 are co-planar or collinear. In addition the bottom surface 64 of the soluble film zone and the lower surface 68 of the pressure sensitive adhesive zone may be co-planar or collinear.

FIG. 5 shows a product showing an alternative pattern of discontinuous soluble film zones 70, wherein the soluble film zones 70 are configured as a series of repeating diamonds.

FIG. 6 shows a product showing an alternative pattern of the discontinuous soluble film zones 72 wherein the soluble film zones 72 are a series of repeating curved stripes.

FIG. 7 are photographs showing a multilayer beauty care product, applied to the skin, comprising a soluble film zone wherein in the left photograph the soluble film zone has a first visual state and the soluble film zone changes from the first visual state to a second visual state in the right photograph.

FIG. 7 are photographs showing a product and/or soluble film zone having an Opacity Change Index of about 2.5 to about 50 wherein the soluble film zone or product changes from a first visual state, for example having a higher opacity in the left photograph, to a second visual state, for example having a lower opacity that is visually discernable to the user, in the right photograph. In an aspect the change from a first visual state to a second visual state is a result of the solubility of the polymers of the soluble film zone as determined by a change in the Opacity referred to as the Opacity Change Index.

The product of FIG. 7 has a backing layer of foamed EVA, Durotak 1093 adhesive available from Henkel. and a soluble film of Methocel E5LV, a cellulose either available from Dow Chemicals. The backing layer is described in U.S. Patent Serial Nos. 62/257,341; 62/257,347 and 62/257,351, assignee Procter & Gamble, each filed on Nov. 19, 2015. An alternative for the water soluble film forming polymer is Polyox such as Polyox WSR N750 available from Dow Chemical.

FIG. 8 is a photograph showing a soluble film cast on a Mylar backing. FIG. 8 shows a soluble film of Polyox with a molecular weight of 200.000 cast on a Mylar backing with no glycerin present. Thus FIG. 8 is a photograph, after subjected to the Opacity Change Index Test Method herein, showing a product and/or soluble film zone wherein the soluble film zone comprises a second visual state. This soluble film zone does not change from a first visual state to a second visual state when subjected to the Opacity Test and the Opacity Change Index is approximately 1. Thus the first visual state (not shown) of the sample shown in FIG. 8 is approximately the same as the second visual state.

FIG. 9 is a photograph showing a soluble film cast on a Mylar backing wherein the soluble film comprises a second visual state. FIG. 9 show a photograph of a soluble film of Polyox with a molecular weight of 200,000, having 37% glycerin, cast on a Mylar backing. FIG. 9 shows a second visual state. This soluble film has an Opacity Change Index of about 40. Thus the first visual state, not shown, of the sample is significantly more opaque that the second visual state.

FIG. 10 shows the impact of including different levels of plasticizer on the dissolution of the soluble film zone in a low water environment. The 200K is Polyox WSR N-80, the 300K is Polyox WSR N-750, the 900K is Polyox WSR N-1105, all available from Dow Chemical Company.

FIG. 11 represents Franz cell penetration for data for (A) in an oil in water emulsion applied without occlusion; (B) an oil in water emulsion occluded by polyethylene terephthalate (PET) film; (C) Methocel E5LV film applied without occlusion; and (D) Methocel E5LV film occluded by PET film. Both the emulsions and the Methocel films each contained 2% inositol. These data demonstrate that the Methocel E5LV in the form of a dry film, without occlusion via a backing layer, does not or only minimally releases inositol, but when it is occluded, the Methocel E5LV film dissolves and the inositol is released. The same is true for the emulsion. Thus the backing layers herein that provide occlusion via e.g. low WVTR, increase delivery of the active to the skin. Franz cell apparatus may be used for the in-vitro assessment of penetration of actives such as inositol through a skin mimic after the application of the sample following pre-treatment with a protective composition. Penetrated actives such as inositol may be quantified using Reverse Phase High Performance (or Pressure) Liquid Chromatography (RP-HPLC) with external standard quantitation at 240 nm. See, for example, the Franz cell procedure in P&G's EP2561856 A1.

Barrier Patch

In an aspect the barrier patch may comprise a backing layer having a first surface and a second surface and a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h; and a pressure sensitive adhesive zone, having a upper surface and a lower surface, and the pressure sensitive adhesive may be in contact with the first surface of the backing layer.

The backing layer may be a co-extruded film laminate comprising at least two layers, but can comprise 3, 4, 5, 6, or more layers. In an aspect the backing layer or product or non-foamed first layer is substantially free of apertures.

“Apertures” as used herein means films having openings of a size and shape that allow for liquid molecules to pass through the film.

The barrier patch of the present invention may comprise a solid sheet material. The sheet provides the primary structure and shape to the product, allowing it to be handled and applied for treatment of a specific target area of the skin.

In certain aspects, backing layer is generally made of a flexible film material which is capable of remaining fitted and flexing during the movement of the human body and movements especially associated with facial expressions or gestures. By “flexible” it is meant that the product, barrier patch, and/or the backing layer may be substantially bent or folded without breaking, tearing, ripping, etc.

In an aspect the product or barrier patch also does not collapse or fold under gravity or upon handling and application by the user. It is desirable for the product to conform to the target area of the skin surface to which it is applied without folding, crinkling, or inducing more wrinkling of the target area of the skin. Accordingly, the product or barrier patch is readily conformable to the skin and remains flexible throughout the duration of use, as the user moves during the period of time worn.

In certain aspects a feature of the subject product is that the barrier patch, adhesive zone, and/or the backing layer are substantially free of, comprises only non-effective amounts of, or is free of or void of, a skin active agent. As such, the barrier patch, the adhesive zone, and/or the backing layer of the present invention may be characterized as a “blank” backing layer, adhesive zone, or barrier patch. In this regard, in an aspect, an effective amount of the skin active agent employed in the product herein is substantially separate from the barrier patch, the adhesive zone, and/or the backing layer. In an aspect the pressure sensitive adhesive zone and water soluble film zone are substantially separate. The term “substantially separate” as used herein means that one component is substantially free of the other component.

In one aspect the backing layer may be a laminate comprising a film and a non-woven material for example, cotton, rayon, acrylic fibers, polypropylene fibers, polyester fibers and combinations, provided that the laminate comprises a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h.

The one or more layers of the barrier patch may comprise at least one material that includes but is not limited to polypropylene (PP); polyethylene (PE), metallocene plastomers, metallocene elastomers, high density polyethylene (HDPE), rubber modified LDPE, rubber modified LLDPE, acid copolymers, polysytyrene, cyclic polyolefins, polyethylene terephthalate (PET); polyvinylchloride (PVC); polyamide (PA); polycarbonate; polyurethane; cellulose acetate; polychloropene; polysulfone; polytetrafluoroethylene (PTFE); polyvinyl acetate (PVA); polyethylene glycol terephthalate film; polystyrene; polyphenylene oxide (PPO); acrylonitrile butadiene styrene (ABS); acrylic; acrylonitrile styrene acrylate (ASA); ethylene vinyl alcohol, natural rubber, latex, nylon, nitrile, silicone and thermo plastic elastomers (TPE), ethylene vinyl acetate (EVA), ethylene acrylic acid (EAA), copolymers of PE with PP, bimodal resins, any of which may be from either homopolymers or copolymers, and blends and combinations of these materials. Blends may be physical blends or reactor blends. The layers may comprise a single polymer or mixtures of polymers or copolymers. Laminates of these layer materials may also be used.

The backing layer(s) herein may comprise polyethylene. The term “polyethylene” or “PE” is used herein the broadest sense to include PE of any of a variety of resin grades, density, branching length, copolymer, blend, catalyst, and the like. The layer may comprise a blend of different grades of polyethylene, that may include LLDPE, LDPE, VLDPE, HDPE, or MDPE, or combinations thereof; manufactured using Ziegler-Natta catalysts, Chromium catalysts, metallocene based catalysts, single site catalysts, and other types of catalysts. The polymers may be homopolymers or copolymers. Blends may be physical blends or reactor blends. These materials can be bio-based, petro-based and recycled/reground. LLDPE copolymers can be made with any one or more of butene, hexene and octene comonomers. The ratio of the different grades can vary.

A preferred material for the one or more layers of the backing layer includes ethylene vinyl acetate, EVA (CAS No. 24937-78-8) copolymer. Different grades of EVAs tend to have different ethylene-to-vinyl acetate monomer ratios and/or different melt indices (molecular weights). For example the percentage of VA monomer may range from about 20% to about 50% or from about 25% to about 40% of VA or from about 25% to about 30% of VA. For example the melt flow index may range from about 0.7 dg/min to about 60 dg/min and/or from about 2 dg/min to about 6 dg/min and/or from about 2 dg/min to about 4 dg/min. EVA grades useful herein include Dupont Elvax® Grades: 260 (28% VA; Melt Flow Index MFI 6 dg/min via ASTM D1238); Grade 250 (28% VA; MFI 25 dg/min); Grade 150 and 150W (32% VA; MFI 43 dg/min); Grade 40 W (40% VA; MFI 52 dg/min); and Celanese Ateva® 2803G (28% VA; MFI 3 dg/min via ASTM D1238) and Ateva® 1807EG (18% VA; MFI 0.7 dg/min).

Another preferred material for the backing layer or barrier patch is a polyethylene film sold under the tradename, 1525L, available from 3M, St. Paul, Minn. 3M 1525-L has a backing of polyethylene film of approximately 3 mil thickness, a 1.4 mil thick hypoallergenic, pressure sensitive acrylate adhesive layer and a paper release layer coated with polyethylene and silicone (3M 1525L may be used without the release layer).

A color masterbatch containing pigment and/or slip/antiblock agent and/or liquid colorants can also be added to the backing layer to afford certain aesthetics and functionality.

Pigments if present may typically be used in concentrations of about 0.5 wt. % to about 15 wt. %, and/or from about 1 wt. % to about 10 wt. %, or from 1.5 wt. % to about 7 wt. %, based on the total weight of the polymer (e.g. of the backing layer).

Other additives are further detailed in U.S. patent publications including U.S. patent application Ser. No. 13/924,983, filed Jun. 24, 2013 (P&G US 2014/0376835; Case 12966Q); and U.S. patent application Ser. No. 13/924,999, filed Jun. 24, 2013 (P&G Case 12967Q), and the references cited therein.

For example the backing layer of the barrier patch optionally can include an additive such as a slip agent or an antistatic agent (e.g., euracamide, a steramide), a filler (e.g., talc, clay, pulp, titanium dioxide, thermoplastic starch, raw starch wood flour, diatomaceous earth, silica, inorganic glass, inorganic salts, pulverized plasticizer, pulverized rubber), a pigment (e.g., mica, titania, carbon black), a UV inhibitor, an anti-coloring agent, a mold release agent, a flame retardant, an electrically conductive agent, an antioxidant, an impact modifier, a stabilizer (e.g., a UV absorber), wetting agents, carbon, graphene and a biodegradable-enhancing additive (e.g., an oxo-degradable additive or an organic material). An oxo-degradable additive is often compounded into a polymer in a concentration of about 1 wt. % to about 5 wt. %, based on the total weight of the polymer, and includes at least one transition metal that can foster oxidation and chain scission in plastics when exposed to heat, air, light, or mixtures thereof. Organic materials (e.g., cellulose, starch, ethylene vinyl acetate, and polyvinyl alcohol) also can be used as biodegradable-enhancing additives.

In a preferred aspect, the multi-layered co-extruded backing layer has at least three layers, and is preferably an ethylene vinyl acetate (“EVA”) comprising film. In a preferred aspect, a foamed layer is in-between non-foamed layers, e.g. a non-foamed first layer and a non-foamed third layer, on either side.

In one aspect the barrier patch comprises a backing layer comprising:

-   -   (i) a non-foamed first layer comprising a non-foamed polymer         film having a first surface;     -   (ii) a foamed second layer comprising a foamed polymer film         comprising a Mean Void Volume Percentage from 45% to 80%,         preferably from 50% to 75%, more preferably from 55% to 73%, and         a thickness of from 10 microns to 250 microns, preferably from         40 microns to 160 microns.

The technique for measuring Mean Void Volume Percentage is described in US Serial Nos. 62/257,341; 62/257,347 and 62/257,351. The degree of foaming of a foamed layer may be characterized by a Mean Void Volume Percentage, as determined by X-ray micro-computed tomography or simply “microCT.”

In one aspect, the foamed layer comprises from 45% to 80% of a Mean Void Volume Percentage (relative to the volume of the foamed layer in total), preferably from 50% to 75%, more preferably from 55% to 73%, Mean Void Volume Percentage.

In an aspect the backing layer of the barrier patch comprises three layers, e.g. a foamed second layer optionally comprising EVA and a layer of non-foamed EVA on either side, i.e., a first non-foamed EVA layer and a third non-foamed EVA layer wherein the foamed EVA layer is in-between said first and third non-foamed layers.

In one aspect the multi-layer barrier patch and/or the backing layer is substantially free of fiber, nanofibers, or non-woven material for example, cotton, rayon, acrylic fibers, polypropylene fibers, polyester fibers.

In another aspect the barrier patch and/or backing layer includes a corona treatment. For example, the backing layer or barrier patch may be additionally treated, for example by corona discharge or coating with an adhesion promoter which as a primer may effect anchoring of the active and adhesive.

The material composition and/or polymer resins used in the foamed layer may be different from those used in the non-foamed layer(s), since the material composition and/or resins may be optimized for foam formation, or other film layer properties. Additives, particularly small amount of nucleating agents selected from the group consisting of CaCO₃, clays, talcs, and combinations thereof, may be included for quick bubble formation during foaming process.

The resin used in making the backing layer(s) of the barrier patch may include renewable materials, either “bio-identical” or “bio-new” materials, or a combination thereof. Some non-limiting options of applicable bio-identical and/or bio-new materials are further detailed in U.S. patent publications from U.S. patent application Ser. No. 13/924,983, filed Jun. 24, 2013 (P&G US 2014/0376835), at pages 15-22; and U.S. patent application Ser. No. 13/924,999, filed Jun. 24, 2013 (P&G US 2014-0377512 A1; P&G Case 12967Q) at pages 12-20. For example the barrier patch may include at least one layer made of a plastic resin. The resin could be a traditional petro-based polyolefin, or it could be a renewable based polyolefin, or a blend thereof. Alternatively it could be a blend comprising a petro-based or renewable based polyolefin blend mixed with a renewable “bio-new” material that is chemically different to traditional petro-based polyolefins. The film layer could be comprised of a material or mixture of materials having a total bio-based content of about 10% to about 100% using ASTM D6866-10, method B. In one aspect, the layer may comprise from about 5% to about 99% by weight of a polymer (A) comprising at least one or possibly more of a low density polyethylene (LDPE), a polar copolymer of polyethylene such as ethylene vinyl acetate (EVA), a linear low density polyethylene (LLDPE), a high density polyethylene homopolymer/high density polyethylene copolymer, a medium density polyethylene, a very low density polyethylene (VLDPE), a plastomer, a polypropylene/copolypropylene/heterophasic polypropylene, polyethylene terephthalate (PET), PLA (e.g., from Natureworks), polyhydroxyalkanoate (PHA), poly(ethylene-2,5-furandicarboxylate) (PEF), cellulose (available from, for example, Innovia), NYLON 11 (i.e., Rilsan® from Arkema), starch (either thermoplastic starch or starch fillers), bio-polyesters, (e.g., those made from bioglycerol, organic acid, and anhydride, as described in U.S. Patent Application No. 2008/0200591, incorporated herein by reference), polybutylene succinate, polyglycolic acid (PGA), and polyvinyl chloride (PVC). At least one of the constituents of polymer (A) may be at least partially derived from a renewable resource. Recycled materials may also be in added. In specific cases, materials that are biodegradable may be utilized.

Some of the “bio-new” materials may further contribute to reflectivity of the film, as the presence of this additional material within the film layer structure can lead to additional light reflectivity, due to their typical incompatibility with the polyolefin matrix.

In one aspect, in order to enable better visibility of the opacity change of the water soluble film zone, the barrier patch is transparent, translucent, and/or visibly clear. In one aspect the barrier patch is transparent. As used herein, “transparent” or “visibly clear” is defined as having the property of transmitting light without appreciable scattering so that bodies lying behind are perceivable. As used herein, “transparent” or “visibly clear” may also be defined as having the property of transmitting light without appreciable scattering so that bodies lying behind are perceivable and that the barrier patch or backing layer is not formed with gas bubbles entrained therein. The term “translucent”, as used herein may include “frosted”, “glittered”, “pearlescence” and the like and is defined herein as the practice of inducing a low level of light scattering into an otherwise “clear” material causing the material to become matted in appearance.

Adhesive Zone

The barrier patch may comprise a backing layer and pressure sensitive adhesive zone. Typically, the pressure sensitive adhesive zone comprises a pressure-sensitive adhesive (PSA) that is suitable for long-term skin contact, and which should be physically and chemically compatible with the backing layer and/or additives that are present. Examples of suitable adhesive materials include, but are not limited to, the following: acrylic and methacrylic ester homo- or copolymers, butyl rubber based systems, silicones, urethanes, vinyl esters and amides, olefin copolymer materials, natural or synthetic rubbers, hot-melt adhesives (see, for example, U.S. Pat. No. 5,387,450); polyethylenes; polysiloxanes; polyisobutylenes; polyacrylates; polyacrylamides; polyurethanes; plasticized ethylene-vinyl acetate copolymers; and tacky rubbers such as polyisobutene, polybutadiene, polystyrene-isoprene copolymers, polystyrene-butadiene copolymers, and neoprene (polychloroprene) and combinations thereof.

According to one aspect the adhesive is a hotmelt adhesive including adhesives selected from the group consisting of ethyl vinyl acetate, metallocene polyalphaolefins, polyolefins including atactic polyalphaolefins, block copolymers such as diblocks copolymers and triblock copolymers, polyurethane hot melts, polyamides and combinations thereof. In one aspect the adhesive comprises a combination of diblock copolymers and triblock copolymers. Diblocks and triblock copolymers may include styrene/isoprene; styrene/butadiene; butylene/ethylene/styrene; and combinations thereof.

High viscosity triblock copolymers may be used as adhesives and have the configuration A-B-A wherein the polymer blocks A are non-elastomeric polymer blocks which, as homopolymers have glass transition temperatures above 20° C. The elastomeric polymer blocks, B, are generally isoprene or butadiene which may be partially or substantially hydrogenated or mixtures thereof. Further, the copolymers may be linear or branched.

Diblock copolymers may generally have the A-B configuration where A and B are as described previously.

Liquid diluents may be added to the adhesive compositions. The adhesive composition may comprise from about 60% to about 99% diluents, by weight. In an aspect the majority of the liquid diluent is oil. Preferably the liquid diluent comprises, or consists essentially of, oils such as highly refined white petroleum mineral oil. Useful diluents are primarily aliphatic in character and compatible with the polymer midblock. Plasticizers may also be included, e.g. paraffinic and naphthenic petroleum oils, highly refined aromatic-free paraffinic and naphthenic food and technical grade oils, highly refined white petroleum mineral oils, and liquid tackifiers such as the synthetic liquid oligomers of polybutene, polypropene, polyterpene, etc. The synthetic process oils may be high viscosity oligomers which may be permanently fluid/liquid monoolefins, isoparaffins or paraffins of moderate to high molecular weight.

In an aspect the adhesive is selected from the TECHNOMELT® and DERMA-TAK® brands available from Henkel, for example TECHNOMELT PSM 154A DERMA-TAK®. DERMA-TAK products are pressure-sensitive adhesives and encompass both solvent-based acrylic and formulated rubber (liquid and hotmelt) pressure-sensitive adhesives. Useful adhesives may also be selected from those described in U.S. Pat. Nos. 6,448,303 and 5,559,165.

In an aspect the pressure sensitive adhesive zones are continuous, discontinuous, or a combination thereof. The product may also comprise a plurality of discontinuous adhesive zones.

Thickness

In one aspect, the overall total thickness of the barrier patch or the product is from 20 microns to 500 microns, preferably from 50 microns to 200 microns, more preferably from 70 to 180 microns, yet more preferably from 75 to 150 microns and combinations thereof.

In another aspect the water soluble film zone (dry state) has a total thickness of about 2 microns to about 200 microns, preferably from 50 microns to about 175 microns, more preferably from about 75 to about 170 microns. In an aspect, the water soluble film zone in the dry state, has a thickness of about 5 microns to about 50 microns, or about 15 microns to about 30 microns.

In an aspect the pressure sensitive adhesive zones typically have an average thickness ranging from about 5 microns to about 350 microns, in alternative aspects about 10 microns to about 120 microns.

In an aspect the typical basis weight for the product herein ranges from about 40 to about 190 gsm, for instance about 45 gsm to about 170 gsm and/or from about 50 gsm to about 140 gsm.

Continuous or Discontinuous Zones

The pressure sensitive adhesive zone and the water soluble film zone may be continuous or discontinuous such that they comprise continuous or discontinuous patterns. In an aspect the adhesive zone and the soluble film zone may both be continuous. In some aspects a portion of the adhesive zone and the soluble film zone are continuous and another portion may be discontinuous. By applying the soluble film zone and the adhesive zone to the backing layer in a discontinuous pattern, a portion of the skin-facing surface of the product and the adhesive zone remains exposed to the skin to permit sufficient adhesion, via the pressure sensitive adhesive, to the skin. In one aspect the soluble film zone should be applied to the adhesive zone so that it covers about 1% to about 99% of the skin facing surface area of the adhesive zone or product, or about 10% to about 90%, and/or about 20% to about 80% of the skin facing surface area of the adhesive zone or the product.

In one aspect the pressure sensitive adhesive zone is applied to the backing layer in a pattern to define a pattern of discontinuous adhesive free areas and the soluble film zone is applied to the adhesive free areas of the backing layer. In another aspect the pressure sensitive adhesive zone is applied to the backing layer in a series of rows or stripes to define a pattern of adjacent adhesive free areas that are stripes or rows, and the soluble film zone is applied to the adhesive free areas/stripes of the backing layer. In another aspect the pressure sensitive adhesive zone is applied to the backing layer as a continuous layer and the soluble film zone is applied, as a discontinuous pattern, to the upper surface of the adhesive zone.

The soluble film zone may be applied to the adhesive zone or the backing layer in a regular pattern, a random pattern, and combinations thereof. For example, the soluble film zone may be configured in either a regular or random pattern of elements such as straight lines, angled lines, curved lines, intersecting lines, dots, circles and geometric shapes, amorphous shaped, etc. or a combination of these elements.

Size and Shape of Product

The product may have a size and shape adapted to conform to a desired target area of skin which could be a human face or part thereof, legs, hands, arms, feet, or human torso. They are generally flat in appearance.

The exact size and shape of the product will depend upon the intended use and product characteristics. The product herein can be, for example, a square, circle, semicircle, rectangle, triangle, oval, ring, crescent, crescent with rounded corners, teardrop or other more complex and irregular shape. The shape of the barrier patch may be selected from the group consisting of circle, square, rectangle, triangle, and/or irregular shape that conforms to the contours of the forehead, perioral, and/or periorbital areas of the human face.

In certain other aspects, the product comprises a size and shape to treat different areas of the face such as the forehead, the under eye area and the under eye area combined with the crows feet area around the eye. Thus the size of the product may be determined by the size of the target area of skin to be treated. Thus a product is shaped to fit the face or the target area of skin the surface area may range from about 0.25 cm² to about 50 cm², and/or from about 1 cm² to about 30 cm², and/or from about 1 cm² to about 20 cm², and/or from about 1 cm² to about 15 cm², and/or from about 5 cm² to about 15 cm². Surface area refers to that of a flat plane having the same boundary as the surface i.e. ignoring any surface texturing present.

WVTR

According to one aspect, the backing layer or barrier patch has an WTVR value between about 1 g/m²/24 h to about 500 g/m²/24 h. and in another aspect has a WVTR from about 1 g/m²/24 h to about 250 g/m²/24 h and/or from about 1 g/m²/24 h to about 180 g/m²/24 h and/or from about 2 g/m²/24 h to about 150 g/m²/24 h and/or from about 2 to about 20 g/m²/24 h. The term WTVR stands for “Water Vapor Transmission Rate”, i.e. the amount of vapor which can pass per unit area during a certain period of time.

The backing layer or barrier patch in certain aspects is non-porous or water impermeable. In certain other aspects the multi-layered barrier patch or backing layer is impermeable to the cosmetic composition, the soluble film zone, the skin care active agent employed, and fluids wherein the WVTR is from about from about 2 to about 100 g/m²/24 h. While not being bound by theory using a backing layer or barrier patch that minimizes water loss from the soluble film or cosmetic composition while in contact with the keratinous tissue and skin, prevents the water soluble film zone or cosmetic composition, once hydrated, from drying out. This drying out may result in reduced or loss of efficacy and/or irritation to the skin.

Such relative water impermeability and lower water vapor permeability of the barrier patch may increase the effectiveness and efficiency of the cosmetic composition. For example, without being bound by theory, the relative water impermeability and lower vapor permeability of the barrier patch employed may serve to enhance or increase the penetration of the skin care active agent into the skin.

In certain aspects the backing layer or barrier patch may, for example, consist of a perforated polyolefin film, where the size of the holes has been chosen so that air and vapor may pass, but not liquid molecules. One example of such film is described in U.S. Pat. No. 5,628,737 and/or micro-porous plastic films, as is described in, for example, EP-A-0238200. These laminates and films, however, are not preferred herein due to their relatively high WVTR and higher levels of breathability.

Release Layer

The product herein may further optionally comprise a protective release layer removably attached to the consumer facing side of the pressure sensitive adhesive or the soluble film zone of the product. The release layer provides protection for the pressure sensitive adhesive zone and/or the soluble film zone from the environment and prior to application by the user.

The protective release layer may comprise materials including polymer resins such as a polyolefins e.g. polypropylene (including stratified biaxially oriented polypropylene (SBOPP)), polyethylene (including LDPE; LLDPE; HDPE; Metallocene) or polyethylene terephthalate, polyesters, and combinations thereof. Alternative materials which may be used include polyvinylchloride, polyamide, acetyl, acrylonitrile butadiene styrene, acrylic, acrylonitrile styrene acrylate, ethylene vinyl alcohol, ethylene vinyl acetate, Nylon, Latex, natural or synthetic rubbers, polycarbonate, polystyrene, silicone or thermo plastic elastomer, thermo plastic vulcanate or copolymers of said materials, and combinations thereof. Where appropriate the protective release layer may comprise one or more laminations, combinations of multiple layers. In an aspect the protective release layer may comprise a coating of a non-stick material. Exemplary non-stick coatings include wax, silicone, fluoropolymers such as TEFLON®, and fluorosilicones.

In an aspect, the protective release layer covers the entire aforementioned area of pressure sensitive adhesive zone coating the barrier patch. In another aspect the protective release layer is water impermeable. In a further aspect, the release layer has a mean thickness of at least about 50 microns, or at least about 85 microns, or from about 50 microns to about 150 microns, and/or from about 90 microns to about 120 microns.

The release layer may optionally extend, in whole or part, beyond the pressure sensitive adhesive zone to provide a removal tab that facilitates ease of removal of the release layer.

Cosmetic Composition

In an aspect the water soluble film zone comprises a cosmetic composition comprising an effective amount of a skin active agent and a water soluble film forming polymer. The composition may also comprise a dermatologically acceptable carrier.

Skin Active Agents

In one aspect the product provides an effective amount of a skin active agent to be delivered to the target area of skin. In another aspect the product provides from about 0.5 mg/cm2 to about 3 mg/cm2 of the cosmetic composition, and/or from about 1 mg/cm2 to about 2 mg/cm2 to the target area of skin. In one aspect and without being bound by theory, the use of the proper amount of the cosmetic composition will minimize the interaction of the cosmetic composition with the pressure sensitive adhesive. The compositions of the present invention may comprise a skin active agent which provides a particular skin care benefit characteristic of the usage of the skin care product. The skin care benefit may include benefits related to appearance or make-up of the skin. The skin care active can provide acute (immediate and short lived) benefits, or chronic (long term and longer lasting) benefits.

The term “skin active agent” as used herein, means an active ingredient which provides a cosmetic and/or therapeutic effect to the area of application on the skin. The skin active agents useful herein include skin lightening agents, anti-acne agents, emollients, non-steroidal anti-inflammatory agents, topical anesthetics, artificial tanning agents, anti-microbial and anti-fungal actives, skin soothing agents, sun screening agents, skin barrier repair agents, anti-wrinkle agents, anti-skin atrophy actives, lipids, sebum inhibitors, sebum inhibitors, skin sensates, protease inhibitors, anti-itch agents, desquamation enzyme enhancers, anti-glycation agents, diaper rash agents, anti-eczema agents, botanicals, and mixtures thereof. When included, the present composition comprises a safe and effective amount of a skin active agent and/or from about 0.0001% to about 20%, in another aspect from about 0.01% to about 10% of at least one skin active agent.

The cosmetic compositions may include from about 0.00001 to about 10% by weight of botanical actives or from about 0.01 to about 8 percent by weight, or from about 0.05 to about 5 percent by weight. “Botanical” herein means a substance, extract or derivative of a plant and may also be described as “herbals”. Botanicals may include water-soluble or oil-soluble active materials extracted from a particular plant including materials extracted from echinacea, yucca glauca, willow herb, basil leaves, Turkish oregano, carrot root, grapefruit fruit, fennel fruit, rosemary, thyme, blueberry, bell pepper, black tea, blackberry, black currant fruit, Chinese tea, coffee seed, dandelion root, date palm fruit, gingko leaf, green tea polyphenols (e.g. epicatechin gallate and epigallocatechin 3-O-gallate), hawthorn berries, licorice, oolong tea, sage, strawberry, sweet pea, tomato, vanilla fruit, neohesperidin, quercetin, rutin, morin, myricetin, chlorogenic acid, glutathione, glycyrrhizin, absinthe, arnica, centella asiatica, chamomelle, comfrey, cornflower, horse chestnut, ivy (Herdera helix), magnolia, mimosa, oat extract, pansey, scullcap, seabuckthorn, white nettle, witch hazel and any combinations thereof.

The type and amount of skin active agents are selected so that the inclusion of a specific agent does not affect the stability of the composition. For example, hydrophilic agents may be incorporated in an amount soluble in the aqueous phase, while lipophilic agents may be incorporated in an amount soluble in the oil phase.

Other skin active agents purported to exhibit expression-line relaxing benefits for use in the present invention include, but are not limited to, Lavandox available from Barnet Products Corporation; Thallasine 2, available from BiotechMarine; Argireline NP, available from Lipotec; Gatuline In-Tense and Gatuline Expression, available from Gattefosse; Myoxinol LS 9736 from BASF Chemical Company, Syn-ake, available from DSM Nutritional Products, Inc.; and Instensyl®, available from Silab, Inc; Sesaflash™, available from Seppic Inc.

Skin lightening agents useful herein refer to active ingredients that improve hyperpigmentation as compared to pre-treatment. Useful skin lightening agents herein include ascorbic acid compounds, vitamin B3 compounds, azelaic acid, butyl hydroxyanisole, gallic acid and its derivatives, glycyrrhizinic acid, hydroquinone, kojic acid, arbutin, mulberry extract, and mixtures thereof. Use of combinations of skin lightening agents is believed to be advantageous in that they may provide skin lightening benefit through different mechanisms.

Ascorbic acid compounds useful herein include ascorbic acid per se in the L-form, ascorbic acid salt, and derivatives thereof. Ascorbic acid salts useful herein include, sodium, potassium, lithium, calcium, magnesium, barium, ammonium and protamine salts. Ascorbic acid derivatives useful herein include, for example, esters of ascorbic acid, and ester salts of ascorbic acid. Particularly preferred ascorbic acid compounds include 2-o-D-glucopyranosyl-L-ascorbic acid, which is an ester of ascorbic acid and glucose and usually referred to as L-ascorbic acid 2-glucoside or ascorbyl glucoside, and its metal salts, and L-ascorbic acid phosphate ester salts such as sodium ascorbyl phosphate, potassium ascorbyl phosphate, magnesium ascorbyl phosphate, and calcium ascorbyl phosphate. Commercially available ascorbic compounds include magnesium ascorbyl phosphate available from Showa Denko, 2-o-D-glucopyranosyl-L-ascorbic acid available from Hayashibara and sodium L-ascorbyl phosphate with tradename STAY C available from Roche.

Vitamin B₃ compounds useful herein include, for example, those having the formula:

wherein R is —CONH₂ (e.g., niacinamide) or —CH₂OH (e.g., nicotinyl alcohol); derivatives thereof; and salts thereof. Exemplary derivatives of the foregoing vitamin B₃ compounds include nicotinic acid esters, including non-vasodilating esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide and niacinamide N-oxide. Preferred vitamin B₃ compounds are niacinamide and tocopherol nicotinate, and in another aspect is niacinamide. In a preferred aspect, the vitamin B₃ compound contains a limited amount of the salt form and is more preferably substantially free of salts of a vitamin B3 compound. Preferably the vitamin B₃ compound contains less than about 50% of such salt, and is more preferably substantially free of the salt form. Commercially available vitamin B₃ compounds that are highly useful herein include niacinamide USP available from Reilly.

Other hydrophobic skin lightening agents useful herein include ascorbic acid derivatives such as ascorbyl tetraisopalmitate (for example, VC-IP available from Nikko Chemical), ascorbyl palmitate (for example available from Roche Vitamins), ascorbyl dipalmitate (for example, NIKKOL CP available from Nikko Chemical); undecylenoyl phenyl alanine (for example, SEPIWHITE MSH available from Seppic); octadecenedioic acid (for example, ARLATONE DIOIC DCA available from Uniquema); oenothera biennis sead extract, and pyrus malus (apple) fruit extract, Water and Myritol 318 and butylene glycol and tocopherol and sscorbil tetraisopalmitate and Paraben and Carbopol 980 and DNA/SMARTVECTOR UV available from COLETICA, magnesium ascorbyl phosphate in hyaluronic filling sphere available from COLETICA, and mixtures thereof.

Other skin active agents useful herein include those selected from the group consisting of N-acetyl D-glucosamine, panthenol (e.g., DL panthenol available from Alps Pharmaceutical Inc.), tocopheryl nicotinate, benzoyl peroxide, 3-hydroxy benzoic acid, flavonoids (e.g., flavanone, chalcone), farnesol, phytantriol, glycolic acid, lactic acid, 4-hydroxy benzoic acid, acetyl salicylic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, cis-retinoic acid, trans-retinoic acid, retinol, retinyl esters (e.g., retinyl propionate), phytic acid, N-acetyl-L-cysteine, lipoic acid, tocopherol and its esters (e.g., tocopheryl acetate: DL-α-tocopheryl acetate available from Eisai), azelaic acid, arachidonic acid, tetracycline, ibuprofen, naproxen, ketoprofen, hydrocortisone, acetominophen, resorcinol, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, 2,4,4′-trichloro-2′-hydroxy diphenyl ether, 3,4,4′-trichlorocarbanilide, octopirox, lidocaine hydrochloride, clotrimazole, miconazole, ketoconazole, neomycin sulfate, theophylline, and mixtures thereof.

The compositions of the present invention in various aspects may comprise N-acyl amino acid compounds. Suitable N-acyl amino acid compounds include, but are not limited to, N-acyl phenylalanine, N-acyl tyrosine, their isomers, including their D and L isomers, salts, derivatives, and mixtures thereof. An example of a suitable N-acyl amino acid is N-undecylenoyl-L-phenylalanine is commercially available under the tradename SEPIWHITE (Registered trademark) from Seppic (France).

Skin care agents are also disclosed in US Publication No. 2007/0020220A1, published Jan. 25, 2007, wherein the components/ingredients are incorporated herein by reference in their entirety.

The cosmetic composition may comprise one or more peptides. Herein, “peptide” refers to peptides containing ten or fewer amino acids, their derivatives, isomers, and complexes with other species such as metal ions (for example, copper, zinc, manganese, and magnesium). As used herein, peptide also refers to both naturally occurring and synthesized peptides. In one aspect, the peptides are di-, tri-, tetra-, penta-, and hexa-peptides, their salts, isomers, derivatives, and mixtures thereof. Examples of useful peptide derivatives include, but are not limited to, peptides derived from soy proteins, palmitoyl-lysine-threonine (pal-KT) and palmitoyl-lysine-threonine-threonine-lysine-serine (pal-KTTKS, available in a composition known as MATRIXYL®) palmitoyl-glycine-glutamine-proline-arginine (pal-GQPR, available in a composition known as RIGIN®), these three being available from Sederma, France. and Cu-histidine-glycine-glycine (Cu-HGG, also known as IAMIN®). In various aspects the cosmetic composition may comprise from about 1×10⁻⁷% to about 20%, alternatively from about 1×10⁻⁶% to about 10%, and alternatively from about 1×10⁻⁵% to about 5% of the peptide.

In one aspect, the skin active agent is niacinamide. In one aspect, the agent is a combination of niacinamide, glycerine, tocopherol acetate, and D-panthenol. Niacinamide may be included in the composition in an amount between about 1% to about 30 wt %, in another aspect from about 2% to about 28 wt %, in another aspect from about 5% to about 25 wt %, and in another aspect from about 10% to about 20 wt %. When D-panthenol is included, it may be present in an amount of about 0.5% to about 5 wt %, or about 0.5% to about 3 wt % and/or about 0.5% to about 2 wt %. Glycerin may be included as an active in an amount from about 6% to about 20 wt %, and/or from about 8% to about 15 wt %, and/or from about 10% to about 15 wt %.

In various aspects, the skin active agent is selected from niacinamide, alone or in combination with one or more of palmitoyl-lysine-threonine, palmitoyl-lysine-threonine-threonine-lysine-serine, N-undecyl-10-enoyl-L-phenylalanine, retinyl propionate, N-acetyl glucosamine, vitamin C, tretinoin, salicylic acid, benzoic acid, benzoyl peroxide, tretinoin, and combinations thereof.

In an aspect the cosmetic compositions herein may be aqueous solutions, or emulsions such as oil-in-water emulsions, water-in-oil emulsions or multiple emulsions having aqueous or oily external phases. In another aspect the cosmetic compositions herein are oil-in-water emulsions.

In one aspect to avoid a negative interaction with the pressure sensitive adhesive, the cosmetic composition or water soluble film zone comprises only low levels of silicones of about 0.5% to about 10%, and/or from about 1% to about 5% and/or the cosmetic composition is substantially free of silicones. As used herein “silicones” may refer to those silicones disclosed in US 2007/0020220A1, published Jan. 25, 2007, Osborne, for example in paragraphs [0226] to [0258].

In one aspect the cosmetic composition is substantially free of depilatory agents.

The cosmetic composition or water soluble film zone may comprise an effective amount of a skin active agent having activity to improve visual or aesthetic appearance of the skin, such as an agent effective to reduce or diminish the appearance of fine lines and/or wrinkles on human facial skin or an agent effective to treating existing acne lesions, reducing redness associated with acne lesions and/or protecting from formation of acne lesions.

In another aspect a method of treating skin is provided, comprising applying the product to a target area of the skin, comprising an effective amount of a skin active agent.

The methods of treatment, application, regulation, or improvement disclosed herein may utilize the aforementioned product and/or multi-layered barrier patch. Application of the present product can occur on any target area of skin surface of the body. Skin surfaces of the most concern tend to be those not typically covered by clothing such as facial skin surfaces, hand and arm skin surfaces, foot and leg skin surfaces, and neck and chest skin surfaces (e.g., decolletage). In particular, application may be on a facial skin surface including the forehead, perioral, chin, periorbital, nose, and/or cheek skin surfaces.

The step of applying the product to a target area of skin may be done by localized application to the target area, for example an area that contains wrinkles. In reference to the application, the term “localized”, “local”, or “locally” mean that it is delivered to the target area of skin (such as an area of skin containing wrinkles) while minimizing delivery to skin surface not requiring treatment.

One or more products of the present invention can be applied broadly to one or more facial skin surfaces to reduce the appearance of wrinkles within those facial skin regions.

The method of treating skin herein may optionally begin with a cleansing step. The consumer can wash his or her face with a suitable cleanser (e.g., Olay Purifying Mud Lathering Cleanser, available from The Procter & Gamble Company, Cincinnati, Ohio), and gently dry his or her skin.

The product may be applied to at least one target portion of skin selected from the group consisting of a forehead, perioral, chin, periorbital, nose, cheek, skin surface, and combinations thereof. The product may be applied to the target portion of skin for a treatment period. The treatment period may comprise at least once a day for at least four weeks, preferably applied at least twice a day for at least four weeks, more preferably at least once a day for at least eight weeks, and more preferably at least twice a day for at least eight weeks, preferably the length of the treatment period is at least 2 weeks, preferably at least 4 weeks, and more preferably at least 8 weeks. The product may remain on the target portion of skin for about 1 minute to about 24 hours or from about 2 hours to about 10 hours, prior to the removal from the skin. In an aspect the target portion of skin comprises a hyperpigmented spot, wrinkles, fine lines, dryness, skin laxity and combinations thereof.

Test Methods Opacity and Opacity Change Index

The opacity is the measure of the capacity of a material to obscure what is in the background.

The Opacity Change Index as used herein measures the change in opacity when the product or water soluble film zone or soluble film sample (made from the water soluble film forming polymer), is subject to the solubility test method herein. The Opacity Change Index is:

Opacity Change Index=Initial Opacity/24 Hour Opacity

To measure the Opacity Change Index of the samples, the following procedure is used. 1. Cut a 3″×3″ sample having a thickness of 25 microns to 100 microns. 2. If the product is not already assembled, apply the soluble film directly to a piece of Mylar and smooth out. Avoid wrinkling the water soluble film if possible. If using a multilayered product comprising a backing layer, an adhesive, and a soluble film, apply the product to a piece of Mylar taking care not to wrinkle the product. Alternatively, if using a multilayered product comprising a backing layer, an adhesive, and a soluble film, it is also acceptable to remove the backing layer and the adhesive from the product and apply the remaining soluble film sample (soluble film may have residual adhesive present or not) to a piece of Mylar taking care not to wrinkle the sample. Use scotch tape to attach the sample to the Mylar on all four sides, with the tape overlapping the sample by ¼″. 3. Once the samples have been prepared as in Step 2 measure the Opacity for the samples according to Step 6 below. This is the Initial Opacity. Then place them in an 85% RH container containing a saturated Potassium Chloride solution. Samples should be arranged so that the Mylar side of the sample is away from the open moist air of the container and the soluble film is facing toward the open moist air of the container. A suitable container is an airtight Smart Locks Keep Box container from the Container Store, made from clarified polypropylene, having a capacity of 8-12 quarts, a lid with an airtight silicone seal and that attaches to the base with four locking clamps. 4. Allow the samples to sit in this container for 24 hours. 5. After 24 hours, take the container with the samples to the Hunter Labscan XE and measure the Opacity. 6. Opacity Measurements. Remove one sample at a time from the container, reclose the container and run the opacity as quickly as possible, within about 1-2 minutes.

-   -   i. Opacity is measured using a 0° illumination/45° detection,         circumferential optical geometry, spectrophotometer with a         computer interface such as the Hunter Color Flex EZ         Spectrophotometer, or equivalent, HunterLab Headquarters, Reston         Va.     -   ii. An effect of normal laboratory temperature and humidity         ranges upon sample color is negligible, thus samples need not be         conditioned prior to determining opacity.     -   iii. Instrument calibration and measurements are made using the         standard white and black calibration plates. Calibrate the         spectrophotometer using standard black and white tiles supplied         with the instrument according to manufacturer's instructions         before beginning any testing. Set the color scale to XYZ, the         Observer to 10° and the illuminant to D65. The instrument is         standardized according to the manufacturer's procedures using         the 0.7 inch port size and 0.5 inch area view. After         calibration, the software is set to the Y opacity procedure         which prompts the operator to cover the sample with either the         white or black calibration tile during the measurement. The         sample is placed over the measurement port. The sample should         completely cover the port with the surface corresponding to the         soluble film surface directed toward the port so that it lies         flat against the port plate. The sample is then covered with the         white standard plate. A reading is taken, then the white tile is         removed and replaced with the black standard tile without moving         the sample. A second reading is taken.     -   iv. The value for opacity is determined by dividing the         reflectance with black backing for the film by the reflectance         obtained for the same material with white backing. This is         called the contrast ratio method whereby the opacity is         calculated as follows:

Opacity=(Y value_((black backing)) /Y value_((white backing))×100

-   -   v. Samples from five identical products or films are analyzed         and their opacity results recorded. The average opacity for the         samples are calculated and reported.         7. Repeat step 6 until done with all samples.         8. Calculate the Opacity Change Index for all of the samples and         record the results.

Opacity Change Index=Initial Opacity/24 Hour Opacity

The Opacity Change Index of the soluble film or product herein is from about 2.5 to about 50, or from about 3 to about 40 or from about 5 to about 20.

WVTR

WVTR of the barrier patch or backing layer is measured according to ASTM F1249 13 at 37° C. and 35% RH. Samples may be analyzed on a MOCON Permatran-W 3/33 Water Vapor Permeability Instrument using ASTM F1249. For samples with higher WVTR (e.g. from approximately 300 g/m²/24 h to 500 g/m²/24 h) samples may be analyzed per ASTM E-96 with desiccant placed inside the test cups and 35% RH surrounding the exterior of the cups. Samples of barrier patches are prepared and do not include the pressure sensitive adhesive.

Basis Weight

Basis Weight is calculated as follows. Sample Preparation: Samples were equilibrated at TAPPI conditions for 100 hours (50% RH, 23° C.). Cut samples to 25.4 mm wide strips using JDC 1″ strip cutter. Cut samples to 80 mm long using gage block. Weigh each sample using 4 place analytical balance. Basis weight is calculated as the sample mass/area, where mass is measured on the balance and area=25.4 mm×80 mm=2032 mm=0.002032 meters. Basis weight is reported in units of grams/meter².

Caliper/Thickness

Thickness measurement may be performed using ASTM D5729 which typically uses a pad caliper with a known pressure (0.1 psi) and a gage sensor. A Qualitest Thickness Tester, Model CHY-C2, available from www.WorldofTest.com may be used.

Dissolution Method

The water soluble film is aged for 24 hours at 21° C. (+/−1.5° C.) and 50% relative humidity (+1-1.5% relative humidity). Cut three test specimens of the water-soluble film sample to a size of 3.8 cm×3.2 cm. Lock each specimen in a separate 35 mm slide mount. Fill a suitable beaker with 500 mL of distilled water, and maintain a constant temperature of 20° C. Mark height of column of water. Place beaker on magnetic stirrer, add magnetic stirring rod to beaker, turn on stirrer, and adjust stir speed until a vortex develops which is approximately one-fifth the height of the water column. Mark depth of vortex. Secure the 35 mm slide mount in an alligator clamp of a slide mount holder such that the long end of the slide mount is parallel to the water surface. The depth adjuster of the holder should be set so that when dropped, the end of the clamp will be 0.6 cm below the surface of the water. One of the short sides of the slide mount should be next to the side of the beaker with the other positioned directly over the center of the stirring rod such that the film surface is perpendicular to the flow of the water. In one motion, drop the secured slide and clamp into the water and start the timer. When all visible film is released from the slide mount, raise the slide out of the water while continuing to monitor the solution for undissolved film fragments. For each sample, record the time when all film fragments of each sample are no longer visible to the naked eye, and the solution becomes clear. Average the time values for the 3 samples and if the average time is 15 minutes or less, then the sample constitutes a water soluble film.

Examples

The following are non-limiting examples of products and methods of the present invention. The examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention, which would be recognized by one of ordinary skill in the art.

In the examples, all concentrations are listed as weight percent, unless otherwise specified and may exclude minor materials such as diluents, filler, and so forth. The listed formulations, therefore, comprise the listed components and any minor materials associated with such components. As is apparent to one of ordinary skill in the art, the selection of these minors will vary depending on the physical and chemical characteristics of the particular ingredients selected to make the present invention as described herein.

A. Preparation of Beauty Care Product:

The following formulation and procedure is used:

Component Weight % Solution A PEG 100 Stearate (surfactant) 1% Emulgade PL 68-50¹ (surfactant) 1% Eutanol G 16² (hexyldecanol) 10% Solution B Sepiwhite MSH (Undecylenoyl 0.4% phenylalanine)³ IN Sodium Hydroxide solution 1.26% Solution C Water 52.34% Niaciniamide 10% Glycerol 20% Inositol 4% ¹Available from BASF. ²Available from BASF. ³Available from BASF.

Mix the ingredients of Solution A and heat to 80° C. with stirring. Then place Solution B ingredients into a small beaker and stir until the solution becomes clear to deprotonate the Sepiwhite MSH to make it soluble in water. Then heat ingredients of Solution C to 80° C. with stirring.

Add Solution B slowly to Solution C with rapid stirring for 10 minutes. Then add Solution A slowly over 15 minutes with rapid stirring at 80° C. and stir for 30 minutes and then mill with a hand held mill for 2 minutes at 80° C. Stir the solution and allow to cool to RT. Once at RT, place the solution into a jar and label. After 96 hours, the solution is stable with no separation and no solids forming.

Once the above emulsions are obtained, to make the water soluble film zone mix a 60:40 ratio mixture of polymer solution to emulsion. Prepare the polymer solution as follows. Place 799.8 g of distilled water into a beaker and stir with an overhead mixer at 500 RPMs. Next, add 0.2 g of phenoxyethanol and stir. Once dispersed, slowly add 200 g of 200 k PEO, Polyox WSR N-80, with a molecular weight of about 200.000 available from Dow, over 45 minutes. Continue stirring at 500 RPMs for 30 minutes. Next, slow the stirring to 200 RPMs and stir for 2 hours. Then mix the polymer solution with the emulsion at a 60:40 ratio mixture of polymer solution to emulsion. Then cast a film with the use of a Gardo Draw Down table and a #44 Draw Down bar, onto a transfer sheet.

Polymer Solution with PEO in Ethanol/Water

An alternative polymer solution may be used and is prepared as follows. Place 535.8 g of ethanol in a beaker and stir with an overhead mixer at 300 RPMs. Then add 0.2 g of phenoxyethanol stir. Once dispersed, add 200 g of 200 k PEO (Polyox WSR N-80, with a molecular weight of about 200,000 available from Dow) and stir at 300 RPMs for 15 minutes to disperse. Once dispersed, add 264 g of distilled water and stir at 100 RPMs for 2 hours. Then mix the polymer solution with the emulsion at a 60:40 ratio mixture of polymer solution to emulsion. Then cast a film with the use of a Gardo Draw Down table and a #44 Draw Down bar, onto a transfer sheet.

Methocel Polymer Solution

An alternative polymer solution may be used and is prepared as follows. Place 799.8 g of distilled water in a beaker and heat to 95 C with stirring from an overhead mixer at 300 RPMs. Once at 95 C, add 0.2 g of phenoxyethanol and stir until dispersed. Next, add Methocel E5LV powder with stirring at 300 RPMs. Once all the Methocel E5LV is added, remove heat and stir the mixture at 300 RPMs until at 60 C. Once at 60 C, turn down the stirring to 150 RPMs and place the beaker in an ice bath and stir until completely hydrated, usually overnight. Then mix the polymer solution with the emulsion at a 60:40 ratio mixture of polymer solution to emulsion. Then cast a film with the use of a Gardo Draw Down table and a #44 Draw Down bar, onto a transfer sheet. The Opacity Change Index for this water soluble film zone is about 5.74 as follows:

ID L* a* b* Opacity Sample METHOCEL WITH 93.21 −0.94 1.55 32.73 5 EMULSION Sample METHOCEL WITH 91.88 −1.25 1.52 5.7 11 EMULSION AFTER 24 HOURS Initial/ 5.742105263 Final

The polymer solutions may be prepared with solvents selected from the group consisting of water, ethanol, isopropanol, propanol, and other water soluble solvents such as alcohols, glycols, and combinations thereof.

Backing and Adhesive Layer

A backing layer according to Sample 3 of Provisional U.S. Patent Application Ser. No. 62/257,341, filed on Nov. 19, 2015, is provided. In particular Sample 3 is a 3 layer film having a foamed core layer and non-foamed outer layers. All layers are made of EVA. The outside layers each have approximately 20 μm thickness and the core foamed layer has approximately 130 μm thickness. The total thickness of the backing layer is approximately 170 μm. The basis weight is about 99 gsm and the WVTR is 82 g/m²/24 hours. The backing layer has a first surface.

Alternatively the backing layer may comprise a low density polyethylene film or a non-foamed laminate of EVA. The backing layer or barrier patch may also comprise a polyethylene film sold under the tradename. 3M 1525L, available from 3M, St. Paul. Minn., (without the release layer) which has a backing of polyethylene film of approximately 3 mil thickness and a 1.4 mil thick hypoallergenic, pressure sensitive acrylate adhesive layer.

Slot coat a pressure sensitive adhesive (if an adhesive is not already present with the backing layer), such as for example, TECHNOMELT® and DERMA-TAK® brands available from Henkel, (for example TECHNOMELT PSM 154A DERMA-TAK®) at a basis weight of about 50 g/m² to about 160 g/m² or specifically about 95 g/m², on the first surface of the backing layer. Slot coat the pressure sensitive adhesive as a continuous layer across the first surface of the backing layer.

After the coating of pressure sensitive adhesive is complete, the upper surface of the pressure sensitive adhesive layer/zone is coated with the above soluble film comprising the skin active agent by contacting the soluble film side of the transfer sheet to the upper surface of pressure sensitive adhesive. The soluble film is coated as a discontinuous layer on the upper (outer) surface of the pressure sensitive adhesive layer/zone. The soluble film has a coating basis weight from about 30 g/m² to about 200 g/m².

The assembly of the barrier patch may also be accomplished by the methods described in US Serial Nos. 62/257,341; 62/257,347 and 62/257,351, assignee Procter & Gamble, each filed on Nov. 19, 2015.

Exemplary products, for example the Product of the above example, for treatment of periorbital skin aging are attached, via the adhesive side, to periorbital area. The Product is applied and worn for an extended period of time of approximately 7-8 hours such as overnight, and thereafter removed. The Products herein deliver an effective amount of the skin active agent in a manner that achieves penetration of the skin active agent into the stratum corneum, and/or other layers of the epidermis, and in many aspects, into the basal skin layer and/or dermis.

The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as “40 mm” is intended to mean “about 40 mm.”

Every document cited herein, including any cross referenced or related patent or application and any patent application or patent to which this application claims priority or benefit thereof, is hereby incorporated herein by reference in its entirety unless expressly excluded or otherwise limited. The citation of any document is not an admission that it is prior art with respect to any invention disclosed or claimed herein or that it alone, or in any combination with any other reference or references, teaches, suggests or discloses any such invention. Further, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition assigned to that term in this document shall govern.

While particular aspects of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention. 

What is claimed is:
 1. A multi-layered beauty care product for applying a skin active agent to the skin, comprising: a water soluble film zone comprising: a water soluble film forming polymer comprising a polymer selected from the group consisting of methylcellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose, and combinations thereof; and a cosmetic composition comprising an oil in water or water in oil emulsion; and an effective amount of a skin active agent; wherein the water soluble film zone has an initial opacity of from about 10 to about 100; a barrier patch comprising: a backing layer having a first surface and a second surface; and a pressure sensitive adhesive zone, having an upper surface and a lower surface, the lower surface of the pressure sensitive adhesive in contact with the first surface of the backing layer; wherein the soluble film zone is in contact with either the first surface of the backing layer, the upper surface of the adhesive zone, or both, and the soluble film zone or product is capable of changing from a first visual state to a second visual state.
 2. The product of claim 1 further comprising an Opacity Change Index that is from about 3 to about
 40. 3. The product of claim 1 wherein the backing layer comprises a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h.
 4. The product of claim 1 wherein the water soluble film forming polymer is used at a level that is in excess of the emulsion, by weight of the water soluble film zone.
 5. The product of claim 4 wherein the water soluble film zone comprises from about 35% to 45% of the emulsion and from about 51% to about 70% of the water soluble film forming polymer.
 6. The product of claim 1 wherein the water soluble film zone further comprises from about 2% to about 80% by weight of the soluble film zone, of a plasticizer.
 7. The product of claim 6 wherein plasticizer is selected from the group consisting of glycerol, ethylene glycol, diethyleneglycol, propylene glycol, sorbitol, pentaerythritol, glucamine, N-methylglucamine, sodiumcumenesulfonate, and combinations thereof.
 8. The product of claim 1 wherein the water soluble film zone and the adhesive zone are substantially separate.
 9. The product of claim 1 wherein the adhesive zone and the water soluble film zone are continuous, discontinuous, or a combination thereof.
 10. The product of claim 9 wherein the product comprises a plurality of discontinuous water soluble film zones.
 11. The product of claim 1 wherein the water soluble film zone further comprises a top surface and a bottom surface.
 12. The product of claim 11 wherein the bottom surface of the soluble film zone is in contact with the upper surface of the adhesive zone and the adhesive zone is continuous.
 13. The product of claim 11 wherein the top surface of the soluble film zone and the upper surface of the adhesive zone are co-planar or collinear.
 14. The product of claim 11 wherein the bottom surface of the soluble film zone and the lower surface of the adhesive zone are co-planar or collinear.
 15. The product of claim 1 wherein the barrier patch or backing layer is water impermeable.
 16. The product of claim 1 wherein the water soluble film zone has a total thickness of about 2 microns to about 200 microns.
 17. The product of claim 1 wherein the barrier patch or product has a total thickness of 20 microns to 500 microns.
 18. The product of claim 1 wherein the product, barrier patch, or backing layer is substantially free of fibrous absorbent materials, superabsorbent materials, non-woven materials, cotton, rayon, acrylics, polypropylene fibers and polyester fibers.
 19. The product of claim 1 wherein the pressure sensitive adhesive is selected from the group consisting of acrylic and methacrylic ester homo- or copolymers, butyl rubber based systems, silicones, urethanes, vinyl esters and amides, olefin copolymer materials, and combinations thereof.
 20. The product of claim 1 wherein the adhesive zone, backing layer, or barrier patch is substantially free of an effective amount of a skin active agent.
 21. The product of claim 1 wherein the backing layer is a laminate comprising a film and a non-woven material.
 22. The product of claim 1 wherein the backing layer comprises a first layer, a second layer and optionally a third layer wherein the second layer is in between the first layer and the third layer and the second layer is optionally foamed.
 23. The product of claim 1 wherein the cosmetic composition comprises from about 0.01% to about 10% of a skin active agent selected from the group consisting of vitamin E, vitamin A, vitamin B, palmitoyl-lysine-threonine, palmitoyl-lysine-threonine-threonine-lysine-serine, N-undecyl-10-enoyl-L-phenylalanine, retinyl propionate, N-acetyl glucosamine, vitamin C, tretinoin, salicylic acid, benzoic acid, benzoyl peroxide, tretinoin, botanicals, and combinations thereof.
 24. The product of claim 1 wherein the barrier patch or backing layer is transparent.
 25. A multi-layered beauty care product for applying a skin active agent to the skin, comprising: a water soluble film zone comprising: a cosmetic composition comprising: an oil in water or water in oil emulsion; and an effective amount of a skin active agent; a water soluble film forming polymer comprising a polymer selected from the group consisting of methylcellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose, and combinations thereof; from about 2% to about 80% by weight of the soluble film zone of a plasticizer; wherein the water soluble film zone has an initial opacity of from about 10 to about 100; a barrier patch comprising: a backing layer having a first surface and a second surface and a WVTR from about 1 g/m²/24 h to about 500 g/m²/24 h; and a pressure sensitive adhesive zone, having an upper surface and a lower surface, the lower surface of the pressure sensitive adhesive in contact with the first surface of the backing layer, wherein the soluble film zone is in contact with either the first surface of the backing layer, the upper surface of the adhesive zone, or both; wherein the adhesive zone or backing layer are substantially free of an effective amount of a skin active agent; wherein the soluble film zone or product is capable of changing from a first visual state to a second visual state with an Opacity Change Index of about 2.5 to about 50 according to the Opacity Test Method.
 26. The product of claim 25 wherein the water soluble film forming polymer is used at a level that is in excess of the emulsion, by weight of the water soluble film zone.
 27. The product of claim 26 wherein the water soluble film zone comprises from about 35% to 45% of the emulsion and from about 51% to about 70% of the water soluble film forming polymer.
 28. The product of claim 25 wherein the barrier patch or backing layer is transparent.
 29. The product of claim 25 wherein the water soluble film zone has a total thickness of about 2 microns to about 200 microns.
 30. The product of claim 25 wherein the barrier patch or product has a total thickness of 20 microns to 500 microns. 